Promoter dna replication
Hem / Historia, Vetenskap & Forskning / Promoter dna replication
1975;255:530–533. Organization of DNA in chromatin. They can be about 100–1000 base pairs long, the sequence of which is highly dependent on the gene and product of transcription, type or class of RNA polymerase recruited to the site, and species of organism.
Transcription factors are ubiquitous proteins that associate with promoter DNA and regulate gene expression through a variety of mechanisms.
Proc Natl Acad Sci U S A. 1994;91:1054–1058. E. coli Fis protein activates ribosomal RNA transcription in vitro and in vivo. [PMC free article: PMC523693] [PubMed: 8036162]
Rojo F, Zaballos A, Salas M. Bend induced by the phage Φ29 transcriptional activator in the viral late promoter is required for activation.
[PubMed: 3065515]
Lloubès R, Lazdunski C, Granger-Schnarr M. et al. Cold Spring Harb Symp Quant Biol. [PubMed: 12595250]
Highlander SK, Weinstock GM. Static DNA bending and protein interactions within the Pasteurella haemolytica leukotoxin promoter region: development of an activation model for leukotoxin transcriptional control.
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Atlung T, Ingmer H. H-NS: a modulator of environmentally regulated gene expression. [PMC free article: PMC453071] [PubMed: 1655421]
Gralla JD. Promoter recognition and mRNA initiation by Escherichia coli Eσ70.
The combination of these elements allows for fine-tuned control over gene activity, and not every eukaryotic promoter has a TATA box.
Prokaryotic organisms, such as bacteria, have a simpler promoter structure with two main consensus sequences. DNA Cell Biol. Cell. [PMC free article: PMC1171423] [PubMed: 10369683]
Gussin GN.
Kinetic analysis of RNA polymerase-promoter interactions. Nucleic Acids Res. 1979;6:1081–1096. [PubMed: 1731201]
Wang L, Winans SC. High angle and ligand-induced low angle DNA bends incited by OccR lie in the same plane with OccR bound to the interior angle.
DNA sequence determinants of LexA-induced DNA bending. Analysis of sequence elements important for the synthesis and control of ribosomal RNA in E. coli. Methods Enzymol. The process is more complicated, and at least seven different factors are necessary for the binding of an RNA polymerase II to the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA.
[PMC free article: PMC306934] [PubMed: 7784181]
Polaczek P, Kwan K, Liberies DA. et al. [PubMed: 3301541]
Ross W, Thompson JF, Newlands JT. et al.